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December 2010 Archives

Japan bio-scientists produce 'singing mouse'

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Agence France-Presse  

TOKYO--Japanese scientists said Tuesday they had produced a mouse that tweets like a bird in a genetically engineered "evolution" which they hope will shed light on the origins of human language.

A team of researchers at the University of Osaka created the animal in their "Evolved Mouse Project", in which they use genetically modified mice that are prone to miscopying DNA and thus to mutations.

"Mutations are the driving force of evolution. We have cross-bred the genetically modified mice for generations to see what would happen," lead researcher Arikuni Uchimura told AFP.

"We checked the newly born mice one by one... One day we found a mouse that was singing like a bird," he said, noting that the "singing mouse" was born by chance but that the trait will be passed on to future generations.

"I was surprised because I had been expecting mice that are different in physical shape," he said by telephone, adding that in fact the project had also produced "a mouse with short limbs and a tail like a dachshund".

The laboratory, directed by professor Takeshi Yagi at the Osaka University's Graduate School of Frontier Biosciences in western Japan, now has more than 100 "singing mice" for further research.

The team hopes they will provide clues on how human language evolved, just as researchers in other countries study songbirds such as finches to help them understand the origins of human language.

Scientists have found that birds use different sound elements, put them together into chunks like words in human languages and then make strings of them to sing "songs", that are subject to certain linguistic rules.

"Mice are better than birds to study because they are mammals and much closer to humans in their brain structures and other biological aspects," Uchimura said.

"We are watching how a mouse that emits new sounds would affect ordinary mice in the same group... in other words if it has social connotations," he said, adding that ordinary mice squeak mainly under stress.

Considering that mutant mice tweet louder when put in different environments or when males are put together with females, Uchimura said their chirps "may be some sort of expressions of their emotions or bodily conditions."

The team has found that ordinary mice that grew up with singing mice emitted fewer ultrasounds than others, which could indicate that communication methods can spread in the same group like a dialect.

Uchimura dreams of further "evolution" of mice through genetic engineering.

"I know it's a long shot and people would say it's 'too absurd'... but I'm doing this with hopes of making a Mickey Mouse some day," he said.
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Science of man-made life can proceed--US panel

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Agence France-Presse

WASHINGTON--A White House panel said on Thursday the controversial field of synthetic biology, or manipulating the DNA of organisms to forge new life forms, poses limited risks and should be allowed to proceed.

An expert commission convened by President Barack Obama advised vigilance and self-regulation as scientists seek ways to create new organisms that could spark useful innovations in clean energy, pollution control and medicine.

Critics, including environmental advocates, accused the panel of not taking their concerns seriously and said that allowing science to police itself was tantamount to offering no oversight at all.

The Presidential Commission for the Study of Bioethical Issues "concluded that synthetic biology is capable of significant but limited achievements posing limited risks," it said in its first report.

"Future developments may raise further objections, but the commission found no reason to endorse additional federal regulations or a moratorium on work in this field at this time."

The 13-member panel of scientists, ethicists and public policy experts was created by Obama last year.

Its first order of business was to consider the issue of synthetic biology after the J. Craig Venter Institute announced in May it had developed the first self-replicating bacteria cell controlled by a synthetic genome.

Those opposed to Venter's techniques said the discovery was tantamount to "playing God," and creating novel organisms that could be dumped into the environment without adequate understanding of the ramifications.

Announcing the creation of the "first synthetic cell," lead researcher Craig Venter said at the time it "certainly changed my views of the definitions of life and how life works."

But the commission said Venter's team had not actually created life, since the work mainly involved altering an already existing life form.

"Thoughtful deliberation about the meaning of this achievement was impossible in the hours that elapsed between the breaking news and the initial round of commentaries that ensued," it said in its report.

"Of note, many scientists observe that this achievement is not tantamount to 'creating life' in a scientific sense because the research required a functioning, naturally occurring host cell to accept the synthesized genome."

Commission chair Amy Gutmann said the panel considered a range of approaches to regulating the new scientific field, from allowing unbridled freedom to imposing strict government regulation on experiments.

"We chose a middle course to maximize public benefits while also safeguarding against risks," she said.

"Prudent vigilance suggests that federal oversight is needed and can be exercised in a way that is consistent with scientific progress."

As to the risk of releasing modified organisms into nature, a scenario some have warned could spark biological threats or damage to the ecosystem, "scientists and ethicists advised careful monitoring and review of the research," the panel said.

The panel also urged greater cooperation among federal agencies that oversee product licensing and funding of synthetic biology, and collaboration with world governments and global groups like the World Health Organization.

"Educational classes on the ethical dilemmas raised by synthetic biology should be a mandatory part of training for young researchers, engineers, and others who work in this emerging field," it added.

A spokesman in the White House's Office of Science and Technology Policy said the Obama administration was "grateful" for the report and highlighted the panel's conclusion that no new regulatory bodies were needed.

"We appreciate the commission's main conclusion that synthetic biology does not currently pose novel safety or ethical issues that require the creation of new oversight bodies," the spokesman said.

A coalition of 58 groups from 22 countries sent a letter of protest to the panel, saying "this process has not resulted in recommendations that recognize the serious threats synthetic biology pose to the environment, workers' health, public health, and social justice."

"We are disappointed that 'business as usual' has won out over precaution in the commission's report," said Eric Hoffman, biotechnology policy campaigner for Friends of the Earth and of the signatories.

"Self-regulation equates to no regulation."
Agence France-Presse  

WASHINGTON--Major crop-killing mildews sneak into plants as "stealth bombers," disguising themselves to thwart plant defenses and cause mass destruction, said research published Thursday in the journal Science.

In a pair of studies, researchers describe how they mapped the genomes of two of the plant-destroyers and detail how the diseases shed giveaway genes that could trigger an immune attack in the plants they invade.

Powdery mildew plagues seem to arise from nowhere and can devastate barley, corn, grapes, potatoes and more, causing huge food losses worldwide particularly in cool, wet climates in North America, Europe and Asia.

Every year, 20 to 40 percent of the world's harvest is lost because of pests, and the new knowledge could help design tougher plants and more potent fungicides to halt their deadly creep.

The diseases -- Blumeria graminis (or barley disease) and Hyaloperonospora arabidopsidis (a flowery, mustard-related plant considered a model for biology research) -- start with tiny parasites that cause dusty white spots on plant leaves and stems.

Farmers have tried to ward off such diseases by rotating crops and treating fields with fungicides, but often the plagues spread too quickly.

Now scientists know why. The organisms are able to disguise themselves so that the plant does not recognize a threat, allowing the fungus to get inside where it can wreak havoc and spread to other plants.

Parasites inside the genome transform themselves, shedding genetic traits so that the plant is confused and does not attack them, explained the study on barley disease that was led by scientists at Imperial College London.

"The mildew is able to evolve so quickly because multiple parasites within the genome, known as 'transposons,' help it to disguise itself and go unrecognized by the plant's defenses," said lead author Pietro Spanu.

"It is as if the transposons confuse the host plant by changing the target molecules that the plant uses to detect the onset of disease."

Downy mildew, another name for the type of disease caused by H. arabidopsidis, is an oomycete, or a fungal-like organism that has evolved from marine algae.

"Hyaloperonospora arabidopsidis is one of the stealth bombers of the world of plant pathogens," said lead author Jim Beynon of Britain's University of Warwick.

"We can see much of how it has actually slimmed down some key elements of its genetic material in order to get around the plant's natural defenses -- essentially by stealth."

The research team also included The Sainsbury Laboratory, and Virginia Polytechnic Institute and State University, also known as Virginia Tech.

John McDowell, an associate professor in Virginia Tech's Department of Plant Pathology, Physiology, and Weed Science, said that by comparing the newly sequenced genomes to other plant pathogens, scientists learned why the mildew is so potent.

"Many plant pathogens contain large families of related genes that serve as powerful weapons but can also trigger equally powerful immune responses in the plant," said John McDowell.

"Our comparisons across multiple genomes revealed that many of these gene families have been reduced in size or completely discarded in H. arabidopsidis.

"This evolution towards stealth helps explain why this mildew and its relatives are widely distributed and cause diseases on many important crops."

Scientists are looking for a genetic solution to the crop-destroyers by developing strains of plants that are resistant to pathogens and pests, now that they know more about the plants' immune systems.

"Such crops will reduce the need to spray pesticides and fungicides and they will give better yields, as less will be lost to disease," said Dale Sanders of the John Innes Centre, a British plant science research institute.
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US scientists create mice from two fathers

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Agence France-Presse

WASHINGTON--US scientists have used stem cell technology to create mice from two fathers, an advance that they say could help preserve endangered species and even help same-sex couples have their own genetic children one day.

According to the study published Wednesday in the journal Biology of Reproduction, reproductive scientists in Texas were able to manipulate cells from a male (XY) mouse fetus to produce an induced pluripotent stem (iPS) cell line.

These iPS cells are adult cells that have undergone some genetic reprogramming in order to enter an embryonic stem cell-like state.

Some of the cells that were grown from this new line spontaneously lost their Y chromosome, turning them into XO cells.

Those XO cells were injected into embryos from donor female mice and transplanted into surrogate mouse moms who gave birth to babies with one X chromosome from the original male mouse.

Those babies grew and later mated with normal male mice. Their offspring, both male and female, showed genetic contributions from two fathers.

The study was led by Richard R. Berhringer at the MD Anderson Cancer Center.

Researchers said that with a variation of their technique, "it may also be possible to generate sperm from a female donor and produce viable male and female progeny with two mothers."

However, the study cautioned that the ability to replicate the findings in humans was a long way off.

The "generation of human iPS cells still requires significant refinements prior to their use for therapeutic purposes," the study said.

Previous research has found ways to create mice without any fathers at all, as well as ways to create mice with two mothers.
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First super-Earth atmosphere analysed--study

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Agence France-Presse

PARIS--Astronomers have for the first time analysed the atmosphere of a "super-Earth," the name given to rocky exoplanets only a few times larger than our own, according to a study released Wednesday.

The breakthrough is a key step in the quest to identify planets in other solar systems that could potentially host forms of life we might recognise, the researchers said.

"We've reached a milestone on the road toward characterising these worlds," said lead author Jacob Bean, a professor at the Harvard-Smithsonian Center for Astrophysics.

The exoplanet in question, dubbed GJ 1214b, is some 42 light years -- four hundred trillion kilometers, or 250 trillion miles -- from our corner of the universe, with a radius about 2.6 times that of Earth.

Discovered last year, GJ 1214b circles a small, faint star, making it that much easier for scientists to tease out data about the atmosphere by analysing starlight as it passes the rim of the planet on its way to us.

Depending on the chemical composition and weather of the atmosphere, specific signature wavelengths of light are absorbed.

Using the European Space Agency's Very Large Telescope in Chile, Bean and colleagues were able to narrow the range of possibilities from three to two.

The first is that GJ 1214b is shrouded by water which -- given the nearness to its star -- would be in the form of steam.

It could also be a rocky world with an atmosphere consisting mostly of hydrogen, but with high clouds or haze obscuring the view.

What the exoplanet is not, the observations prove, is a "mini-Neptune" with a small rocky core and a deep, hydrogen-rich atmosphere.

"Although we can't say yet exactly what that atmosphere is made of, it is an exciting step forward to be able to narrow down the options for such a distant world to either steamy or hazy," said Bean.

In either case, it is more than unlikely that GJ 1214b hosts life forms.

"This planet is much too hot to be considered habitable," Bean told AFP. "In the regions of the atmosphere with pressures similar to what are seen at sea level on Earth, the temperatures are estimated to be more than 500 degree Celsius (930 degrees Fahrenheit)."

It circles its star every 38 hours at a distance of only two million kilometers, seventy times closer than Earth's orbit of the Sun.

Despite this, GJ 1214b is smaller, cooler and more Earth-like than any other known exoplanet.

Most of the more than 500 exoplanets discovered to date are "hot Jupiters", so-called because of their large, gaseous masses and extreme temperatures.

But as observational tools become more powerful, astronomers have begun to identify more and more rocky orbs similar to our own.

"We are working to discover and eventually characterise the atmospheres of planets that would be habitable," said Bean.

"We aren't there yet, but the goal is obtainable within the next decade," he said by email.

No exoplanet discovered so far falls within its solar system's "Goldilocks zone," where temperatures are not so hot that water evaporates, nor so cold that it freezes, but just right for the stuff of life to exist in liquid form.

Earth's atmosphere is 78 percent nitrogen, 21 percent oxygen and one percent other gases, including carbon dioxide.

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'Can't talk now Dad, I'm ovulating'--study

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Agence France-Presse

PARIS--Women instinctively shun their fathers when they are most fertile, even as they seek out the companionship of their mothers, a new study has shown.

The reasons, say the researchers, is evolution. Females in other species have also been observed to give a wide birth to male kin during periods of maximum fertility.

"The behaviour has long been explained as a means of avoiding inbreeding and the negative consequences associated with it," explained lead author Debra Lieberman, a professor at the University of Miami.

"But until we conducted our study, nobody knew whether a similar pattern occurred in women."

Lieberman and colleagues examined cell phone records of 48 women in their reproductive years, noting the date and duration of all calls with their fathers and, separately, their mothers over the course of a billing period.

They found that women called their dads less frequently during the days when the were ovulating, and would hang up sooner if the calls came the other way.

Overall, daughters were half as likely to ring up papa during high fertility days compared to the period of menstruation. What's more, the conversations that did occur lasted about half as long.

The researchers checked to be sure that the women were not giving their dads the slip in order to meet male suitors.

Nor were they simply trying to evade parental control: even when hormones were working overtime, the women were far more, rather than less, likely to give mom a ring.

Women have hard-wired mechanisms that protect against the risk of less healthy children, which tend to occur when close genetic relatives mate, the researchers concluded.

"It makes sense that women would reduce their interactions with male genetic relatives, who are undesirable mates," Lieberman said.

At the same time, when women are in their most fertile phase they are attracted to men with "masculine" qualities such as husky voices and competitive personalities, previous research has shown.

The study was published in the peer-reviewed journal Psychological Science.

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